A Difficult but Important Assignment

Not significant but important.

Armstrong and colleagues report the result of a large Phase IIb randomized trial evaluating the effectiveness of a preparation of the Bowman Birk Inhibitor compared with an oral placebo in reversing the extent of oral leukoplakia as measured visually by pathology or a battery of intermediate end points. In this editorial, we review the report of this negative clinical trials result to highlight...

Fighting Tobacco Smoking - a Difficult but Not Impossible Battle

According to the World Health Organization (WHO), tobacco-related disease is the single largest preventable cause of death in the world today, killing around 5.4 million people a year--an average of one person every six seconds. The total number of death caused by tobacco consumption is higher than that of tuberculosis, HIV/AIDS and malaria combined. Unlike other communicable diseases, however,...

Secondary or therapy-related MDS and AML and their chromosome aberrations: important to study but difficult to establish causality.

Correspondence: Jens Pedersen-Bjergaard, M.D., Ph.D., The Laboratory for Cancergenetics and Cytogenetics, Section 5702, The Finsen Center, Copenhagen University Hospital, Rigshospitalet, 4 Henrik Harpestrengsvej, DK-2100 Copenhagen Ø, Denmark. Phone: international +45-35-454587 • Fax: international +45-35452577. cated by significant differences in the cytogenetic characteristics.5 Further studi...

A New Proof of a “Hard But Important” Sangaku Problem

We present a solution to a well-known sangaku problem, previously solved using the Sawayama Lemma, that does not require it.

Stressing what is important : Orthographic cues and lexical stress assignment